Novel lysophosphoplipid receptors: their structure and function

Kumiko Makide; Akiharu Uwamizu; Yuji Shinjo; Jun Ishiguro; Michiyo Okutani; Asuka Inoue; Junken Aoki

Journal of Lipid Research (Oct 2014)

Novel lysophosphoplipid receptors: their structure and function

Kumiko Makide,
Akiharu Uwamizu,
Yuji Shinjo,
Jun Ishiguro,
Michiyo Okutani,
Asuka Inoue,
Junken Aoki

Affiliations

Kumiko Makide: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; PRESTO Japan Science and Technology Corporation, Saitama, Japan
Akiharu Uwamizu: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Yuji Shinjo: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Jun Ishiguro: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Michiyo Okutani: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Asuka Inoue: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; PRESTO Japan Science and Technology Corporation, Saitama, Japan
Junken Aoki: To whom correspondence should be addressed; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; CREST, Japan Science and Technology Corporation, Saitama, Japan; To whom correspondence should be addressed

Journal volume & issue: Vol. 55, no. 10
pp. 1986 – 1995

Abstract

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It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid. While the roles of some LysoGPs, such as lysophosphatidic acid and sphingosine 1-phosphate, have been thoroughly examined, little is known about the roles of several other LysoGPs, such as lysophosphatidylserine (LysoPS), lysophosphatidylthreonine, lysophosphatidylethanolamine, lysophosphatidylinositol (LPI), and lysophosphatidylglycerol. Recently, a GPCR was found for LPI (GPR55) and three GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS. In this review, we focus on these newly identified GPCRs and summarize the actions of LysoPS and LPI as lipid mediators.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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