PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

Abstract

Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer types.