A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Yangfan Qi; Jing Yu; Wei Han; Xiaojuan Fan; Haili Qian; Huanhuan Wei; Yi-hsuan S. Tsai; Jinyao Zhao; Wenjing Zhang; Quentin Liu; Songshu Meng; Yang Wang; Zefeng Wang

doi:10.1038/ncomms11840

Nature Communications (Jun 2016)

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Yangfan Qi,
Jing Yu,
Wei Han,
Xiaojuan Fan,
Haili Qian,
Huanhuan Wei,
Yi-hsuan S. Tsai,
Jinyao Zhao,
Wenjing Zhang,
Quentin Liu,
Songshu Meng,
Yang Wang,
Zefeng Wang

Affiliations

Yangfan Qi: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Jing Yu: Department of Biostatistics, University of North Carolina at Chapel Hill
Wei Han: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Xiaojuan Fan: Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Haili Qian: State Key Lab of Molecular Oncology, Peking Union Medical College and Chinese Academy of Medical Sciences
Huanhuan Wei: Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Yi-hsuan S. Tsai: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jinyao Zhao: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Wenjing Zhang: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Quentin Liu: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Songshu Meng: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Yang Wang: Institute of Cancer Stem Cell, Second Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University
Zefeng Wang: Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms11840
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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