International Medical Case Reports Journal (Feb 2020)
Juvenile Xanthogranuloma: Case Report and Literature Review
Abstract
Sadegh Vahabi-Amlashi, Masoumeh Hoseininezhad, Zahra Tafazzoli Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranCorrespondence: Zahra TafazzoliDepartment of Dermatology, Imam Reza Hospital, Ibn e Sina Street, Mashhad, IranTel +98 91 51885344Fax +98 51 38583845Email [email protected]: Juvenile Xanthogranuloma (JXG) is a relatively uncommon non-Langerhans cell histiocytosis, which often occurs at an early age and is usually asymptomatic. Herein, we present the case of a 17-year-old man with numerous asymptomatic yellow-brown papulonodular lesions with a symmetric distribution on upper and lower extremities, face, and trunk, developed over the past 4 years. In the histopathologic examination, histiocytes with a Touton-like appearance were observed in favor of xanthogranuloma. The patient was treated with isotretinoin 20 mg daily for 2 months, which surprisingly led to the progression of lesions and thus was discontinued. Although JXG may cause severe morbidities in some circumstances, it is a self-limiting benign disorder and patients should be assured regarding the benign self-regressive nature of the disease.Keywords: non-langerhans-cell histiocytosis, isotretinoin, adult, Juvenile Xanthogranulomas
