Nature Communications (Nov 2019)
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
- Nicholas J. W. Rattray,
- Drupad K. Trivedi,
- Yun Xu,
- Tarani Chandola,
- Caroline H. Johnson,
- Alan D. Marshall,
- Krisztina Mekli,
- Zahra Rattray,
- Gindo Tampubolon,
- Bram Vanhoutte,
- Iain R. White,
- Frederick C. W. Wu,
- Neil Pendleton,
- James Nazroo,
- Royston Goodacre
Affiliations
- Nicholas J. W. Rattray
- School of Chemistry, Manchester Institute for Biotechnology, University of Manchester
- Drupad K. Trivedi
- School of Chemistry, Manchester Institute for Biotechnology, University of Manchester
- Yun Xu
- School of Chemistry, Manchester Institute for Biotechnology, University of Manchester
- Tarani Chandola
- Cathie Marsh Institute for Social Research, University of Manchester
- Caroline H. Johnson
- Department of Environmental Health Sciences, Yale School of Public Health, Yale University
- Alan D. Marshall
- Cathie Marsh Institute for Social Research, University of Manchester
- Krisztina Mekli
- Cathie Marsh Institute for Social Research, University of Manchester
- Zahra Rattray
- Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
- Gindo Tampubolon
- Cathie Marsh Institute for Social Research, University of Manchester
- Bram Vanhoutte
- Cathie Marsh Institute for Social Research, University of Manchester
- Iain R. White
- School of Chemistry, Manchester Institute for Biotechnology, University of Manchester
- Frederick C. W. Wu
- Faculty of Medical and Human Sciences, Institute of Human Development, Centre for Endocrinology and Diabetes, Andrology Research Unit, Manchester Academic Health Sciences Centre, University of Manchester
- Neil Pendleton
- Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester Salford Royal Hospital
- James Nazroo
- Cathie Marsh Institute for Social Research, University of Manchester
- Royston Goodacre
- School of Chemistry, Manchester Institute for Biotechnology, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-019-12716-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Risk of age-related chronic disorders and decrease in resilience is associated with ageing. Here the authors analyse the human blood metabolome and identify metabolites associated with frailty.
