Investigation of the Inhibition Action of Antiviral Preparation 1 – Boraadamantane Concerning the Flu Virus

Abstract

In this work, the surface-active properties of 1- boraadamantane have been studied on the model of monomolecular phospholipid monolayers. Compression isotherms for the phospholipid monolayer are received, before the addition of 1-bromoadamantane in a concentration of 10-7-10-6 M. From the analysis of the compression isotherms generated, it is possible to conclude that at a concentration of 1-bromoadamantane (10-6M), an increase in the area falling on one phospholipid molecule occurs. The increase in the area falling on one single phospholipid molecule leads to a reduction in the frequency of the action of the lateral diffusion of the phospholipid molecules, a potential difference of the monolayer and a reduction in a corner of an arrangement of the phospholipid molecules to the monolayer surface. The specified phenomena can lead to a decrease in the degree of interaction of the viral membrane and a cell membrane. Also, in this work, study was done on the activity of virion RNA-dependent RNA - polymerase after interaction with various concentrations of 1- boraadamantane.

Keywords

• 1- boraadamantane
• flu virus
• phospholipid monolayers
• compression isotherms
• virion RNA - dependent RNA - polymerase.