Introduction: Pain in the lumbosacral spine is a substantial problem of modern civilization. It leads to lowering the quality of life and to the reduced functioning in social and professional context. This problem mainly affects people with sedentary work such as drivers and office workers. Long-term work in one position and a frequent lack of physical activity are two of the factors conducive to the occurrence of pain in people doing work in a sitting position. Aim of the study: To assess the influence of Kaltenborn-Evejth manual therapy techniques on the quality of life of people doing sedentary work. Material and Method: The research was carried out in the Medi-Sport Rehabilitation and Sports Center from March to October 2018. The study included 60 people doing sedentary work of which 37 were women and 23 men. The Oswestry Questionnaire was the research tool. In the study group there were 21 people aged 30-40, 23 aged 41-50 and 16 aged 51-60. Results: The use of Kaltenborn-Evejth manual therapy techniques in people doing sedentary work reduced pain in the lumbosacral spine, improved its functions, which improved the quality of life of patients. After the therapy, the severity of pain in the lumbosacral spine decreased. Conclusions: Techniques of Kaltenborn-Evejth manual therapy mobilization significantly reduce pain in the lumbosacral spine, which improves the quality of life of persons performing sedentary work. The severity of pain in the lumbosacral spine decreased after the therapy.