Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis

Reza Rezaei Javan; Elisa Ramos-Sevillano; Asma Akter; Jeremy Brown; Angela B. Brueggemann

doi:10.1038/s41467-019-12825-y

Nature Communications (Oct 2019)

Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis

Reza Rezaei Javan,
Elisa Ramos-Sevillano,
Asma Akter,
Jeremy Brown,
Angela B. Brueggemann

Affiliations

Reza Rezaei Javan: Nuffield Department of Medicine, University of Oxford
Elisa Ramos-Sevillano: UCL Respiratory, Division of Medicine, University College London
Asma Akter: Department of Medicine, Imperial College London
Jeremy Brown: UCL Respiratory, Division of Medicine, University College London
Angela B. Brueggemann: Nuffield Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-12825-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Prophages are viral genomes integrated within bacterial genomes. Here, Rezaei Javan et al. identify nearly 800 prophages and satellite prophages in > 1300 Streptococcus genomes, and show that a satellite prophage is associated with virulence in a mouse model of pneumococcal infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal