Pain Research and Management (Jan 2020)
Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial
- Mohammad Jafar Eghbal,
- Ali Haeri,
- Arash Shahravan,
- Ali Kazemi,
- Fariborz Moazami,
- Mohammad Ali Mozayeni,
- Eshaghali Saberi,
- Mohammad Samiei,
- Mehdi Vatanpour,
- Alireza Akbarzade Baghban,
- Mahta Fazlyab,
- Ardavan Parhizkar,
- Mahboobe Ahmadi,
- Nazila Akbarian Rad,
- Shima Bijari,
- Delaram Bineshmarvasti,
- Paria Davoudi,
- Roya Dehghan,
- Mandana Dehghani,
- Habibollah Ebrahimi,
- Nafiseh Emami,
- Nafiseh Farajian,
- Rahim Fereidooni,
- Gelareh Ghobadi,
- Mostafa Ghodrati,
- Atefeh Gohari,
- Azadeh Hashemi,
- Mohammadreza Hosseini,
- Elham Karami,
- Nasir Kheirabadi,
- Sepideh Kozegari,
- Hadi Labaf Ghasemi,
- Alireza Majidi,
- Parastu Malekzadeh,
- Vahid Mehrabi,
- Mehrnush Mohammadi,
- Leila Moradi Eslami,
- Atefeh Noghani,
- Negin Omatali,
- Negar Pourhatami,
- Behnam Rahbani Nobar,
- Saeid Rahmani,
- Parviz Shafaq,
- Sara Soofiabadi,
- Somaye Teimoori,
- Farzaneh Vatandoost,
- Saeed Asgary
Affiliations
- Mohammad Jafar Eghbal
- Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Ali Haeri
- Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Arash Shahravan
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Ali Kazemi
- Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran
- Fariborz Moazami
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Mohammad Ali Mozayeni
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Eshaghali Saberi
- Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran
- Mohammad Samiei
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Mehdi Vatanpour
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Alireza Akbarzade Baghban
- Department of Basic Sciences, Proteomics Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran 1616913111, Iran
- Mahta Fazlyab
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Ardavan Parhizkar
- Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Mahboobe Ahmadi
- Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran
- Nazila Akbarian Rad
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Shima Bijari
- Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran
- Delaram Bineshmarvasti
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Paria Davoudi
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Roya Dehghan
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Mandana Dehghani
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Habibollah Ebrahimi
- Endodontic Department, Oral and Dental Diseases Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran
- Nafiseh Emami
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Nafiseh Farajian
- Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran
- Rahim Fereidooni
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Gelareh Ghobadi
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Mostafa Ghodrati
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Atefeh Gohari
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Azadeh Hashemi
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Mohammadreza Hosseini
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Elham Karami
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Nasir Kheirabadi
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Sepideh Kozegari
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Hadi Labaf Ghasemi
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Alireza Majidi
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Parastu Malekzadeh
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Vahid Mehrabi
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Mehrnush Mohammadi
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Leila Moradi Eslami
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Atefeh Noghani
- Endodontic Department, Dental School, Tabriz University of Medical Sciences, Tabriz 5166614713, Iran
- Negin Omatali
- Endodontic Department, Dental Branch, Islamic Azad University, Tehran 1946853314, Iran
- Negar Pourhatami
- Endodontic Department, Dental School, Shiraz University of Medical Science, Shiraz 7134814336, Iran
- Behnam Rahbani Nobar
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Saeid Rahmani
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Parviz Shafaq
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Sara Soofiabadi
- Endodontology Research Center, Endodontic Department, Dental School, Kerman University of Medical Sciences, Kerman 7618751689, Iran
- Somaye Teimoori
- Endodontic Department, Dental School, Shahed University, Tehran 1417755351, Iran
- Farzaneh Vatandoost
- Endodontic Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- Saeed Asgary
- Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
- DOI
- https://doi.org/10.1155/2020/5853412
- Journal volume & issue
-
Vol. 2020
Abstract
This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. In seven academic centers, 550 cariously exposed pulps were included and randomly allocated into PMTA (n = 188), PCEM (n = 194), or RCT (n = 168) arms. Preoperative “Pain Intensity” (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. Patients’ demographic and pre-/intra-/postoperative factors/conditions were recorded/analysed. The arms were homogeneous in terms of demographics. The mean preoperative PIs were similar (P=0.998), the mean sum PIs recorded during 10 postoperative intervals were comparable (P=0.939), and the trend/changes in pain relief were parallel (P=0.821) in all study arms. The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (P=0.578). The time span of endodontic procedures was statistically different; RCT = 69.73, PMTA = 35.37, and PCEM = 33.62 minutes (P<0.001). Patients with greater preoperative pain, symptomatic apical periodontitis, or presence of PDL widening suffered more pain (P=0.002, 0.035, and 0.023, resp.); however, other pre-/intra-/postoperative factors/conditions were comparable. Pulpotomy with MTA/CEM and RCT demonstrate comparable and effective postoperative pain relief.
