A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones

Abstract

Novel 1-phenyl-piperazine-2,6-diones were prepared by a new facile synthetic routeusing methyl N-substituted iminomonoacetate as starting material. The structures of thesecompounds were established by 1H-NMR, 13C-NMR and GC/MS. 2-(4-Chloro-5-cyclo-pentyl-oxy-2-fluorophenyl)-tetrahydro-2H-pyrido-[1,2-a]-pyrazine-1,3-(4H,6H)-dione displayed thegreatest herbicidal activity.

Keywords

• 1-Phenyl-piperazine-2
• 6-dione
• 2-phenyl-tetrahydro-2H-pyrido-[1
• 2-a]-pyrazine- 1
• 3-(4H
• 6H)-dione
• 2-phenyl-tetrahydropyrrolo[1
• 2-a]pyrazine-1
• 3(2H
• 4H)- dione
• herbicide
• synthesis.