Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates

Abstract

Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage. Recently, research has focused on characterizing the content of extracellular vesicles (EVs), particularly microRNAs (miRNAs), for diagnostic use. Here, we describe the most recent work on EVs-miRNAs biomarkers discovery for conditions that commonly affect premature neonates.

Keywords

• neonate
• prematurity
• bronchopulmonary dysplasia
• necrotizing enterocolitis
• hypoxic-ischemic brain damage
• extracellular vesicles