Nature Communications (Jan 2022)
Maternal regulation of biliary disease in neonates via gut microbial metabolites
- Jai Junbae Jee,
- Li Yang,
- Pranavkumar Shivakumar,
- Pei-pei Xu,
- Reena Mourya,
- Unmesha Thanekar,
- Pu Yu,
- Yu Zhu,
- Yongkang Pan,
- Haibin Wang,
- Xufei Duan,
- Yongqin Ye,
- Bin Wang,
- Zhu Jin,
- Yuanmei Liu,
- Zhiqing Cao,
- Miki Watanabe-Chailland,
- Lindsey E. Romick-Rosendale,
- Michael Wagner,
- Lin Fei,
- Zhenhua Luo,
- Nicholas J. Ollberding,
- Shao-tao Tang,
- Jorge A. Bezerra
Affiliations
- Jai Junbae Jee
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Li Yang
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Pranavkumar Shivakumar
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Pei-pei Xu
- Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Reena Mourya
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Unmesha Thanekar
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Pu Yu
- Department of Neonatal Surgery, Xi’an Children’s Hospital
- Yu Zhu
- Department of Pediatrics, Western China Second Hospital, Sichuan University
- Yongkang Pan
- Department of Neonatal Surgery, Xi’an Children’s Hospital
- Haibin Wang
- Department of Pediatric Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xufei Duan
- Department of Pediatric Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Yongqin Ye
- Department of General Surgery, Shenzhen Children’s Hospital
- Bin Wang
- Department of General Surgery, Shenzhen Children’s Hospital
- Zhu Jin
- Department of Pediatric General Thoracic and Urology Surgery, The Affiliated Hospital of Zunyi Medical University
- Yuanmei Liu
- Department of Pediatric General Thoracic and Urology Surgery, The Affiliated Hospital of Zunyi Medical University
- Zhiqing Cao
- Department of Pediatric Surgery, Jiangmen Maternity and Child Health Care Hospital
- Miki Watanabe-Chailland
- Division of Pathology, Cincinnati Children’s Hospital Medical Center
- Lindsey E. Romick-Rosendale
- Division of Pathology, Cincinnati Children’s Hospital Medical Center
- Michael Wagner
- Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Lin Fei
- Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Zhenhua Luo
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- Nicholas J. Ollberding
- Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center
- Shao-tao Tang
- Department of Pediatrics, University of Cincinnati, College of Medicine
- Jorge A. Bezerra
- Divisions of Gastroenterology, Hepatology and Nutrition and The Liver Care Center at Cincinnati Children’s Hospital Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-27689-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in newborn mice.
