Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases
Masanari Kuwabara,
Tomoko Fukuuchi,
Yuhei Aoki,
Einosuke Mizuta,
Motoshi Ouchi,
Masafumi Kurajoh,
Tatsuya Maruhashi,
Atsushi Tanaka,
Nagisa Morikawa,
Kensuke Nishimiya,
Naoyuki Akashi,
Yoshihiro Tanaka,
Naoyuki Otani,
Mihoko Morita,
Hiroshi Miyata,
Tappei Takada,
Hiroshi Tsutani,
Kazuhide Ogino,
Kimiyoshi Ichida,
Ichiro Hisatome,
Kohtaro Abe
Affiliations
Masanari Kuwabara
Department of Cardiology, Toranomon Hospital, 2-2-2-Toranomon, Minato, Tokyo 105-8470, Japan
Tomoko Fukuuchi
Laboratory of Biomedical and Analytical Sciences, Faculty of Pharma-Science, Teikyo University, Itabashi, Tokyo 173-8605, Japan
Yuhei Aoki
Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Takamatsu 761-0793, Kagawa, Japan
Einosuke Mizuta
Department of Cardiology, Sanin Rosai Hospital, Yonago 683-8605, Tottori, Japan
Motoshi Ouchi
Department of Health Promotion in Nursing and Midwifery, Innovative Nursing for Life Course, Graduate School of Nursing, Chiba University, Chiba 260-8672, Chiba, Japan
Masafumi Kurajoh
Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka 5454-8585, Osaka, Japan
Tatsuya Maruhashi
Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Hiroshima, Japan
Atsushi Tanaka
Department of Cardiovascular Medicine, Saga University, Saga 849-8501, Saga, Japan
Nagisa Morikawa
Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan
Kensuke Nishimiya
Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai 980-8574, Miyagi, Japan
Naoyuki Akashi
Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Saitama, Japan
Yoshihiro Tanaka
Division of Epidemiology, Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka 420-0881, Shizuoka, Japan
Naoyuki Otani
Cardiovascular Center, Dokkyo Medical University Nikko Medical Center, Nikko 321-1298, Tochigi, Japan
Mihoko Morita
Department of Hematology and Oncology, University of Fukui Hospital, Eiheiji 910-1193, Fukui, Japan
Hiroshi Miyata
Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan
Tappei Takada
Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan
Hiroshi Tsutani
National Hospital Organization Awara Hospital, Awara 910-4272, Fukui, Japan
Kazuhide Ogino
Department of Cardiology, Japanese Red Cross Tottori Hospital, Tottori 680-8517, Tottori, Japan
Kimiyoshi Ichida
Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan
Ichiro Hisatome
National Hospital Organization Yonago Medical Center, Yonago 683-0006, Tottori, Japan
Kohtaro Abe
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Fukuoka, Japan
The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters.
