Toxins (Oct 2014)

Efficacy of Active Carbon towards the Absorption of Deoxynivalenol in Pigs

  • Mathias Devreese,
  • Gunther Antonissen,
  • Patrick De Backer,
  • Siska Croubels

DOI
https://doi.org/10.3390/toxins6102998
Journal volume & issue
Vol. 6, no. 10
pp. 2998 – 3004

Abstract

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In order to assess the in vivo efficacy of mycotoxin binders, specific toxicokinetic parameters should be measured according to European guidelines. For this purpose, an absorption model in pigs is described with emphasis on absorption kinetics. Pigs received a single oral bolus of the mycotoxin deoxynivalenol alone or in combination with active carbon (applied as mycotoxin binder). After administration of deoxynivalenol alone, significant plasma amounts of deoxynivalenol were detected and kinetic parameters were calculated using a one compartmental model. Activated carbon completely prevented the absorption of deoxynivalenol as no plasma amounts could be detected.

Keywords