Chronic obstructive pulmonary disease (COPD): influence of clinic-anamnestic, anthropometric and functional characteristics on serum α-1-anitrypsin (AAT) in stable patients.

Abstract

Aim of the study – to enhance the diagnostic and treatment tactics of stable COPD patients management at out patient stage by studying the serum AAT. Data of 45 outpatients with COPD (GOLD I-IV) and 20 healthy persons were included into analysis. Sex, age, height, weight, body mass index (BMI), smoking status were assessed. Lung function and serum AAT were measured. These results suggest that sex, age, height, weight, BMI do not influence on serum AAT both in stable COPD patients and healthy persons. Serum AAT statistically significant negatively correlate with airways obstruction degree in stable COPD patients. Significant moderate negative correlation between serum AAT and number of exacerbation during last year was found in stable COPD patients. This finding allows to suggest that serum AAT could be used as an indicator for COPD prognosis.

Keywords

• COPD
• exacerbation
• α-1-antitrypsin