PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

• Peter P Lee,
• Stephen J Forman,
• Xiuli Wang,
• Tanya B Dorff,
• Jelani C Zarif,
• Yukiko Yamaguchi,
• Jackson Gibson,
• Kevin Ou,
• Lupita S Lopez,
• Rachel H Ng,
• Neena Leggett,
• Vanessa D Jonsson,
• Catalina Martinez,
• Saul J Priceman

Affiliations

Peter P Lee

3 Department of Immuno-Oncology, City of Hope National Medical Center, Duarte, California, USA

Stephen J Forman

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA

Xiuli Wang

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA

Tanya B Dorff

2 Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Jelani C Zarif

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Yukiko Yamaguchi

City of Hope National Medical Center, Duarte, CA, USA

Jackson Gibson

City of Hope National Medical Center, Duarte, CA, USA

Kevin Ou

City of Hope National Medical Center, Duarte, CA, USA

Lupita S Lopez

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA

Rachel H Ng

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA

Neena Leggett

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA

Vanessa D Jonsson

Department of Applied Mathematics, University of California, Santa Cruz, California, USA

Catalina Martinez

Department of Clinical and Translational Project Development, City of Hope, Duarte, CA, USA

Saul J Priceman

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA