Human adult hippocampal neurogenesis in health and disease
MC. Alonso-Moreno,
M. Gallardo-Caballero,
AV. Prádanos-Senén,
M. Llorens-Martín
Affiliations
MC. Alonso-Moreno
Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC)–Universidad Autónoma de Madrid (UAM), Madrid, Spain; Center for Networked Biomedical Research On Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Department of Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain
M. Gallardo-Caballero
Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC)–Universidad Autónoma de Madrid (UAM), Madrid, Spain; Center for Networked Biomedical Research On Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Department of Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain
AV. Prádanos-Senén
Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC)–Universidad Autónoma de Madrid (UAM), Madrid, Spain; Department of Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain
M. Llorens-Martín
Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC)–Universidad Autónoma de Madrid (UAM), Madrid, Spain; Center for Networked Biomedical Research On Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Department of Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain; Corresponding author at: Centro de Biología Molecular “Severo Ochoa”, Spanish Research Council (CSIC), Universidad Autónoma de Madrid (campus de Cantoblanco), c/Nicolás Cabrera 1, 28049 Madrid, Spain.
The mammalian hippocampus generates new dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), participates in hippocampal functions such as memory and mood regulation. Moreover, AHN is impaired in mouse models and patients with neurodegenerative and psychiatric disorders. Additionally, physiological aging targets AHN and the integrity of the hippocampal neurogenic niche. This perspective review aims to discuss the regulation of human AHN in patients with neurodegenerative and psychistric conditions. Moreover, we will address key adaptations of human AHN and the neurogenic niche in response to physiological aging.
