Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Oct 2000)
Effect of Caffeine on the retention and retrieval of memory in mice
Abstract
Objective: Caffeine consumption may reinforce and/or deteriorate memory and learning this is related to the dose of caffeine. The effect of caffeine on retention and retrieval of memory in mice, by using of passive avoidance learning was investigated. Methods: For this purpose after weighing, coding and grouping, the mice were examined as follows: a) Test group that received electric shock and caffeine (5 mg/kg). B) Control group that received electric shock and saline (IP). C) Shame group that only received electric shock. The latency period for both retention and retrieval tests of memory in all three groups of mice were measured. Caffeine was injected immediately after an electric shock in the retention test of memory and 23,30´ hours after electric shock in the retrieval test of memory. Findings: Obtained results indicate that caffeine (5 mg/kg) reinforced retention of memory, but in comparison with control group, there was no significant difference and also it caused to reinforces retrieval of memory, but in comparison with control group, there was a significant difference. Conclusion: The results indicate that caffeine (5 mg/kg) has no effect on retention of memory, but it reinforces the retrieval of memory.
