Association Between Staphylococcal Enterotoxin-Specific IgE and House-Dust-Mite-Specific IgE in Brazilian Patients with Chronic Rhinosinusitis with Nasal Polyps
Priscilla Campos,
Sérgio Duarte Dortas Junior,
Solange Oliveira Rodrigues Valle,
Nathalia Novello Ferreira,
Fabiana Chagas da Cruz,
Priscila Novaes Ferraiolo,
José Elabras Filho
Affiliations
Priscilla Campos
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Sérgio Duarte Dortas Junior
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Solange Oliveira Rodrigues Valle
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Nathalia Novello Ferreira
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Fabiana Chagas da Cruz
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Priscila Novaes Ferraiolo
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
José Elabras Filho
Department of Allergy and Immunology and Department of Otolaryngology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil
Chronic Rhinosinusitis (CR) is a common inflammatory condition with complex pathophysiology involving multiple interleukins. In times of precision medicine, it is mandatory to cluster our patients to offer the best tailored treatment with the lowest cost possible. Therefore, some triage markers can be used towards this goal, without raising much financial burden. The aim of this study was to identify the association of staphylococcal enterotoxin (SE)-specific IgE of types A, B, C, and TSST-1 (toxic shock syndrome toxin-1); and total IgE (tIgE) and specific IgE for Dermatophagoides pteronyssinus (DP), Dermatophagoides farinae (DF), and Blomia tropicalis (BT) in Brazilian patients with CRSwNP. Thirty-six patients with CSRwNP were analyzed for serum IgE levels: tIgE and specific IgE for: DP, DF, BT, and SE types A, B, C, TSST-1 by ImmunoCAP®. The mean value of tIgE in SE-specific IgE-positive patients was 767 IU/mL and in house-dust-mite (HDM)-positive patients, the mean tIgE was 319 IU/mL (p p p = 0.014). We found an association between high levels of tIgE and SE-specific IgE in patients with CRSwNP, possibly related to local and peripheric polyclonal IgE production. The mean value of tIgE—with a suggested cutoff point of tIgE levels of 767 IU/mL—can be used as a triage biomarker for positive SE-specific IgE in CRSwNP patients.
