International Journal of General Medicine (Jul 2024)
Modified TI-RADS Coupled with BRAFV600E Enhances Diagnostic Efficiency in Papillary Thyroid Carcinoma: Prospective Study
Abstract
Jing Wang, Hong Cheng, Xu Li Department of Ultrasound, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing, 402760, People’s Republic of ChinaCorrespondence: Xu Li, Tel +86-13637920860, Email [email protected]: Thyroid disorders, relatively common diseases of the endocrine system, have risen gradually in recent years. Early detection and accurate diagnosis of thyroid cancer hold exceptional importance. This study aimed to determine the efficacy of a modified TI-RADS and BRAFV600E mutation testing for thyroid cancer (PTC) diagnosis.Methods: Ninety five thyroid nodules (48 benign and 47 malignant) from 81 patients were examined using Kwak Thyroid Imaging Reporting and Data System (TI-RADS) were subjected to shear wave elasticity (SWE), BRAFV600E genotyping and fine needle aspiration (FNA) cytology.Results: The modified TI-RADS exhibited superior diagnostic accuracy compared to TI-RADS in differentiating benign nodules from malignant thyroid nodules. Moreover, the AUC of modified TI-RADS in conjunction with BRAFV600E was the highest at 95% CI (0.898– 0.992, p=0.003), surpassing other diagnostic methods in enhanced sensitivity and maintaining high specificity.Conclusion: The diagnostic efficiency of this combination surpassed that of individual diagnostic methods.Keywords: modified TI-RADS, shear wave elasticity, stiff rim sign, BRAFV600E, papillary thyroid cancer
