Journal of the Brazilian Chemical Society (Jan 2006)

Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

  • Simões Simone S.,
  • Medeiros Everaldo P.,
  • Gaião Edvaldo N.,
  • Lyra Wellington S.,
  • Moreira Pablo N. T.,
  • Araújo Mario C. U.,
  • Silva Edvan C.,
  • Nascimento Valberes B.

Journal volume & issue
Vol. 17, no. 3
pp. 609 – 613

Abstract

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A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.

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