Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Yi Han; Qiong Jia; Pedram Shafiei Jahani; Benjamin P. Hurrell; Calvin Pan; Pin Huang; Janet Gukasyan; Nicholas C. Woodward; Eleazar Eskin; Frank D. Gilliland; Omid Akbari; Jaana A. Hartiala; Hooman Allayee

doi:10.1038/s41467-020-15649-3

Nature Communications (Apr 2020)

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Yi Han,
Qiong Jia,
Pedram Shafiei Jahani,
Benjamin P. Hurrell,
Calvin Pan,
Pin Huang,
Janet Gukasyan,
Nicholas C. Woodward,
Eleazar Eskin,
Frank D. Gilliland,
Omid Akbari,
Jaana A. Hartiala,
Hooman Allayee

Affiliations

Yi Han: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Qiong Jia: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Pedram Shafiei Jahani: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Benjamin P. Hurrell: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Calvin Pan: Department of Human Genetics, David Geffen School of Medicine at UCLA
Pin Huang: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Janet Gukasyan: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Nicholas C. Woodward: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Eleazar Eskin: Department of Computer Science and Inter-Departmental Program in Bioinformatics, University of California, Los Angeles
Frank D. Gilliland: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Omid Akbari: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jaana A. Hartiala: Department of Preventive Medicine, Keck School of Medicine, University of Southern California
Hooman Allayee: Department of Preventive Medicine, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-020-15649-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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