Open Medicine
(Oct 2024)
ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
Wang Ying,
Chang Jiang,
Wang Fa,
Lai Lianying,
Yang ShiXu,
Fu Yueying,
Ma Xingtian,
Yun Chuan
Affiliations
Wang Ying
Department of General Practice, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China
Chang Jiang
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China
Wang Fa
Department of Anesthesiology, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, China
Lai Lianying
Department of Nephrology, Hainan Medical University, Haikou, 570102, Hainan, China
Yang ShiXu
Department of Nephrology, Hainan Medical University, Haikou, 570102, Hainan, China
Fu Yueying
Department of Nephrology, Hainan Medical University, Haikou, 570102, Hainan, China
Ma Xingtian
Department of Nephrology, Hainan Medical University, Haikou, 570102, Hainan, China
Yun Chuan
Department of Endocrinology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China
DOI
https://doi.org/10.1515/med-2024-1037
Journal volume & issue
Vol. 19,
no. 1
Abstract
Read online
Adenosine deaminases acting on RNA 1 (ADAR1), an RNA editing enzyme, holds a role in cancer, inflammation, and immunity. However, its specific function in the nephropathy and high-glucose-induced human renal tubular epithelial cells (HK-2) injury in diabetic db/db mice is not clear.
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