A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance

Kaspar Broch, MD, PhD; Trine Popperud, MD, PhD; Einar Gude, MD, PhD; Yngvar Fløisand, MD, PhD; Ellen-Ann Antal, MD, PhD; Gerhard Bosse, MD; Christoffer Jonsrud, MD, PhD; Terje Hegard, MD; Silje Skaara, MD; Ahmed Elsais, MD, PhD

JACC: Case Reports (May 2020)

A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance

Kaspar Broch, MD, PhD,
Trine Popperud, MD, PhD,
Einar Gude, MD, PhD,
Yngvar Fløisand, MD, PhD,
Ellen-Ann Antal, MD, PhD,
Gerhard Bosse, MD,
Christoffer Jonsrud, MD, PhD,
Terje Hegard, MD,
Silje Skaara, MD,
Ahmed Elsais, MD, PhD

Affiliations

Kaspar Broch, MD, PhD: Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Address for correspondence: Dr. Kaspar Broch, Department of Cardiology, Oslo University Hospital, Rikshospitalet Sognsvannsveien 20, 0382 Oslo, Norway.
Trine Popperud, MD, PhD: Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Einar Gude, MD, PhD: Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Yngvar Fløisand, MD, PhD: Department of Hematology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Ellen-Ann Antal, MD, PhD: Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway
Gerhard Bosse, MD: Department of Radiology and Nuclear Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
Christoffer Jonsrud, MD, PhD: Department of Medical Genetics, University Hospital of North Norway, Tromsø, Norway
Terje Hegard, MD: Department of Medicine, Telemark Hospital Trust, Notodden Hospital, Notodden, Norway
Silje Skaara, MD: Department of Neurology, Telemark Hospital Trust, Skien, Norway
Ahmed Elsais, MD, PhD: Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway

Journal volume & issue: Vol. 2, no. 5
pp. 785 – 789

Abstract

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A 48-year-old man presented with rapidly progressive heart failure and monoclonal gammopathy of uncertain significance. No specific cause was detected on endomyocardial biopsy. As the heart failure worsened, he also developed progressive skeletal myopathy. This provided the clue to the diagnosis, and cardiac function recovered rapidly with cause-directed therapy. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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