Communications Biology (Aug 2022)
Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages
- Wei-Chiao Huang,
- Moustafa T. Mabrouk,
- Luwen Zhou,
- Minami Baba,
- Mayumi Tachibana,
- Motomi Torii,
- Eizo Takashima,
- Emily Locke,
- Jordan Plieskatt,
- C. Richter King,
- Camila H. Coelho,
- Patrick E. Duffy,
- Carole Long,
- Takafumi Tsuboi,
- Kazutoyo Miura,
- Yimin Wu,
- Tomoko Ishino,
- Jonathan F. Lovell
Affiliations
- Wei-Chiao Huang
- Department of Biomedical Engineering, University at Buffalo, State University of New York
- Moustafa T. Mabrouk
- Department of Biomedical Engineering, University at Buffalo, State University of New York
- Luwen Zhou
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Minami Baba
- Division of Molecular Parasitology, Proteo-Science Center, Ehime University
- Mayumi Tachibana
- Division of Molecular Parasitology, Proteo-Science Center, Ehime University
- Motomi Torii
- Division of Molecular Parasitology, Proteo-Science Center, Ehime University
- Eizo Takashima
- Division of Malaria Research, Proteo-Science Center, Ehime University
- Emily Locke
- PATH’s Malaria Vaccine Initiative (MVI)
- Jordan Plieskatt
- PATH’s Malaria Vaccine Initiative (MVI)
- C. Richter King
- PATH’s Malaria Vaccine Initiative (MVI)
- Camila H. Coelho
- Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Patrick E. Duffy
- Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Carole Long
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Takafumi Tsuboi
- Division of Malaria Research, Proteo-Science Center, Ehime University
- Kazutoyo Miura
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yimin Wu
- PATH’s Malaria Vaccine Initiative (MVI)
- Tomoko Ishino
- Division of Molecular Parasitology, Proteo-Science Center, Ehime University
- Jonathan F. Lovell
- Department of Biomedical Engineering, University at Buffalo, State University of New York
- DOI
- https://doi.org/10.1038/s42003-022-03688-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that both block transmission and prevent infection.
