High Doses of Inhaled Nitric Oxide as an Innovative Antimicrobial Strategy for Lung Infections
Lorenzo Del Sorbo,
Vinicius S. Michaelsen,
Aadil Ali,
Aizhou Wang,
Rafaela V. P. Ribeiro,
Marcelo Cypel
Affiliations
Lorenzo Del Sorbo
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Vinicius S. Michaelsen
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Aadil Ali
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Aizhou Wang
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Rafaela V. P. Ribeiro
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Marcelo Cypel
Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, 101 College Street | PMCRT, Toronto, ON M5G 1L7, Canada
Since the designation of nitric oxide as “Molecule of the Year” in 1992, the scientific and clinical discoveries concerning this biomolecule have been greatly expanding. Currently, therapies enhancing the release of endogenous nitric oxide or the direct delivery of the exogenous compound are recognized as valuable pharmacological treatments in several disorders. In particular, the administration of inhaled nitric oxide is routinely used to treat patients with pulmonary hypertension or refractory hypoxemia. More recently, inhaled nitric oxide has been studied as a promising antimicrobial treatment strategy against a range of pathogens, including resistant bacterial and fungal infections of the respiratory system. Pre-clinical and clinical findings have demonstrated that, at doses greater than 160 ppm, nitric oxide has antimicrobial properties and can be used to kill a broad range of infectious microorganisms. This review focused on the mechanism of action and current evidence from in vitro studies, animal models and human clinical trials of inhaled high-dose nitric oxide as an innovative antimicrobial therapy for lung infections.
