Frontiers in Medicine (Jan 2022)

Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage

  • Qing Xu,
  • Xinting Wang,
  • Zhengpei Zhang,
  • Jie Li,
  • Haiyang Liu,
  • Sujuan Ji,
  • Lei Qiao,
  • Chaoju Gong,
  • Ruifang Feng,
  • Suyan Li

DOI
https://doi.org/10.3389/fmed.2021.797223
Journal volume & issue
Vol. 8

Abstract

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We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like material adhering to the the posterior pole retinal surface in both eyes. Visual acuity significantly improved after the first vitrectomy, but vitreous opacities recurred 4 years later. The patient appeared to have aggravated sensorimotor neuropathy and severe autonomic dysfunction at the same time. He developed intraoperative suprachoroidal hemorrhage during the second vitrectomy.

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