ENDOTHELIAL DYSFUNCTION IN DEVELOPMENT OF VARICOSE VEINS OF LOWER EXTREMITIES AND POSSIBILITIES OF IT’S CORRECTION

Abstract

Purpose: To study pathologic processes of the venous wall, prior to the appearance of it’s irreversible changes for prevention of venous diseases and improve results of treatment of patients with varicose veins of lower extremities.Materials and Methods: Conditions of endothelium was studied in 92 patients with varicose veins of lower extremities by determining the level of markers of endothelial dysfunction: P-selectin, E-selectin, tissue plasminogen activator, endothelin-1, adhesion molecules vascular endothelial type 1 (sVCAM-1), circulating endothelial cells.Results and Summary: the severity of examined markers can be an indication of the activity of varicose processes of transformation veins. Patients with varicose veins of lower extremities in postoperative and long-term follow-up are advisable to determine commissions, VCAM-1, P - and E-selectins, t-PA and endothelin-1 in order to perform diagnostics of the functional state of the endothelium, inflammatory processes in varicose veins. Indicators of endothelial dysfunction prospectively also be used to monitor the effectiveness of conservative treatment of chronic venous insufficiency.

Keywords

• varicose veins of lower extremities
• a comprehensive treatment of endothelial dysfunction