Kidney transplantation outcomes: Single center experience

Jamilya Saparbay; Mels Assykbayev; Saitkarim Abdugafarov; Gulnur Zhakhina; Saniya Abdrakhmanova; Aida Turganbekova; Zhuldyz Zhanzakova; Kulkayeva Gulnara

Transplantation Reports (Sep 2022)

Kidney transplantation outcomes: Single center experience

Jamilya Saparbay,
Mels Assykbayev,
Saitkarim Abdugafarov,
Gulnur Zhakhina,
Saniya Abdrakhmanova,
Aida Turganbekova,
Zhuldyz Zhanzakova,
Kulkayeva Gulnara

Affiliations

Jamilya Saparbay: Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan; Corresponding author: Jamilya Saparbay, Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan. Telephone: +77767223974.
Mels Assykbayev: Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan
Saitkarim Abdugafarov: Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan
Gulnur Zhakhina: Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan
Saniya Abdrakhmanova: Scientific and Production Center of Transfusiology, Ministry of Healthcare of the Republic of Kazakhstan, Kerey Zhanibek khandar 10, Nur-Sultan, Kazakhstan
Aida Turganbekova: Scientific and Production Center of Transfusiology, Ministry of Healthcare of the Republic of Kazakhstan, Kerey Zhanibek khandar 10, Nur-Sultan, Kazakhstan
Zhuldyz Zhanzakova: Scientific and Production Center of Transfusiology, Ministry of Healthcare of the Republic of Kazakhstan, Kerey Zhanibek khandar 10, Nur-Sultan, Kazakhstan
Kulkayeva Gulnara: Department of hepatology, gastroenterology and organ transplantation, LLP «National Research Oncology Center», Kerey and Zhanibek khandar street 3, 01-0000, Nur-Sultan, Kazakhstan

Journal volume & issue: Vol. 7, no. 3
p. 100105

Abstract

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Introduction: Chronic kidney disease (CKD) is one of the main burden for healthcare system not only in Kazakhstan. The number of patients with CKD increases annually. Among renal replacement approaches, kidney transplantation (KTx) is the best therapeutic option. KTx is performed in Kazakhstan since 2010. Various factor can either improve or deteriorate outcome after KTx. Here we analyzed factors, influencing graft survival. We have performed this study in order to detect the factors, that significantly affects the KTx outcomes, preferably from living donorMethods: Clinical data of the 253 kidney recipients were collected from archives of National Research oncology center and retrospectively analyzed.Results: Immunological status before KTx was found to affect outcome. The presence of HLA class I antibodies was significantly related to graft loss (p=0.046).Coexistence of HLA class II antibodies and the graft loss was not significant (p=0.324). Acute postoperative rejection was highly correlated with graft loss (p<0.001). Of the cohort, 18 (7%) had acute rejection, and 13 (72%) of them were women (p<0.001). The graft survival was statistically significantly related to the gender of the recipient with p=0.002. The 5-year survival of a graft in females was 80.2%, while for males it was 95.3%. In addition, post-operational complications remarkably influenced the graft loss with p=0.005Conclusion: Recipients' gender, immunological status, and acute graft rejection episodes after transplantation were predictors of a worse kidney function 1 year after transplantation.

Published in Transplantation Reports

ISSN: 2451-9596 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: https://www.journals.elsevier.com/transplantation-reports/

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