Celecoxib: evaluation of its efficacy and safety in the second decade of the 21st century

Abstract

Celecoxib is an effective drug to control chronic pain in rheumatic diseases. It is the only nonsteroidal antiinflammatory drug that has clearly shown the lower frequency of not only upper, but also distal gastrointestinal complications, such as iron-deficiency anemia associated with small bowel pathology. In real clinical practice, the reflection of which is populationbased studies, celecoxib causes cardiovascular events relatively rarely. Its good tolerability and a low risk for gastrointestinal and cardiovascular complications allow its successful use for a long time (if required), without fear of drug-induced complications.

Keywords

• нестероидные противовоспалительные препараты
• ревматические заболевания
• желудочно-кишечные, сердечно-сосудистые осложнения
• целекоксиб