Pharmacophylogeny of genus Allium L

Abstract

The genus Allium is well known for its ethnomedicinal significances. It comprises over 1,100 species with diverse therapeutic potentials. This study explores the pharmacophylogeny of Allium, integrating traditional knowledge with modern scientific methods. The investigation compass 139 distinct medicinal categories, including 610 utilization records from 168 published sources, offering a comprehensive understanding of Allium species for diverse therapeutic applications especially antidiabetic and antioxidant properties. Phylogenetic analysis reveals distinct clades with significant antidiabetic and antioxidant activities, in 42 out of 185 species of genus Allium. This is supported by the presence of bioactive compounds such as allicin, flavonoids, phenolics etc. A heat map systematically depicts the ethnomedicinal relevance of various Allium species within clades, illuminating their potential contributions to human health. These findings emphasize the evolutionary convergence of pharmacological traits within specific lineages. By integrating traditional medicinal knowledge with modern scientific methodologies, this study pioneers a holistic approach to harnessing the therapeutic potential of natural plant resources, particularly within the diverse genus Allium. This interdisciplinary approach offers promising avenues for drug discovery and healthcare enhancement, emphasizing the importance of integrating traditional wisdom with scientific inquiry in harnessing the therapeutic potential of Allium species.

Keywords

• Allium
• Pharmacophylogeny
• Therapeutic uses
• Antidiabetic
• Antioxidant
• Ethnomedicinal