Nature Communications (Sep 2021)

Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates

  • Cayla A. Wood,
  • Sangheon Han,
  • Chang Soo Kim,
  • Yunfei Wen,
  • Diego R. T. Sampaio,
  • Justin T. Harris,
  • Kimberly A. Homan,
  • Jody L. Swain,
  • Stanislav Y. Emelianov,
  • Anil K. Sood,
  • Jason R. Cook,
  • Konstantin V. Sokolov,
  • Richard R. Bouchard

DOI
https://doi.org/10.1038/s41467-021-25452-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Photoacoustic imaging is limited by a lack of contrast agents which can enable combined molecular and physiological imaging at depth. Here the authors address these limitations by developing and validating a contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green dye.