Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir

Abstract

Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2–98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.

Keywords

• baloxavir
• baloxavir marboxil
• drug susceptibility
• zoonotic influenza
• avian influenza
• influenza viruses