Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

Juil Kim; Yuseok Moon

doi:10.1038/s42003-021-02078-1

Communications Biology (May 2021)

Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

Juil Kim,
Yuseok Moon

Affiliations

Juil Kim: Laboratory of Mucosal Exposome and Biomodulation, Department of Integrative Biomedical Sciences and Biomedical Research Institute, Pusan National University
Yuseok Moon: Laboratory of Mucosal Exposome and Biomodulation, Department of Integrative Biomedical Sciences and Biomedical Research Institute, Pusan National University

DOI: https://doi.org/10.1038/s42003-021-02078-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing insights into environmental stress-mediated signaling in CRC.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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