Nature Communications (Apr 2017)
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations
- David Brown,
- Dominiek Smeets,
- Borbála Székely,
- Denis Larsimont,
- A. Marcell Szász,
- Pierre-Yves Adnet,
- Françoise Rothé,
- Ghizlane Rouas,
- Zsófia I. Nagy,
- Zsófia Faragó,
- Anna-Mária Tőkés,
- Magdolna Dank,
- Gyöngyvér Szentmártoni,
- Nóra Udvarhelyi,
- Gabriele Zoppoli,
- Lajos Pusztai,
- Martine Piccart,
- Janina Kulka,
- Diether Lambrechts,
- Christos Sotiriou,
- Christine Desmedt
Affiliations
- David Brown
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- Dominiek Smeets
- Laboratory of Translational Genetics, Vesalius Research Center, VIB
- Borbála Székely
- Second Department of Pathology, Semmelweis University
- Denis Larsimont
- Department of Pathology, Institut Jules Bordet
- A. Marcell Szász
- Second Department of Pathology, Semmelweis University
- Pierre-Yves Adnet
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- Françoise Rothé
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- Ghizlane Rouas
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- Zsófia I. Nagy
- Second Department of Pathology, Semmelweis University
- Zsófia Faragó
- Second Department of Pathology, Semmelweis University
- Anna-Mária Tőkés
- Second Department of Pathology, Semmelweis University
- Magdolna Dank
- Semmelweis University Cancer Center, Semmelweis University
- Gyöngyvér Szentmártoni
- Semmelweis University Cancer Center, Semmelweis University
- Nóra Udvarhelyi
- Surgical and Molecular Tumor Pathology Centre, National Institute of Oncology
- Gabriele Zoppoli
- University of Genova and Istituto di Cura a Carattere Clinico e Scientifico Azienda Ospedaliera Universitaria San Martino—Instituto Nazionale Tumori
- Lajos Pusztai
- Yale University
- Martine Piccart
- Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles
- Janina Kulka
- Second Department of Pathology, Semmelweis University
- Diether Lambrechts
- Laboratory of Translational Genetics, Vesalius Research Center, VIB
- Christos Sotiriou
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- Christine Desmedt
- Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles
- DOI
- https://doi.org/10.1038/ncomms14944
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Tumour heterogeneity is well-known; however, studies analysing the progression from primary to metastatic disease are still limited. Here, the authors used phylogenetic analyses and found that for some patients there are multiple seeding events from the primary tumour accompanied by cross-seeding between metastases.
