TET-mediated epimutagenesis of the Arabidopsis thaliana methylome

Lexiang Ji; William T. Jordan; Xiuling Shi; Lulu Hu; Chuan He; Robert J. Schmitz

doi:10.1038/s41467-018-03289-7

Nature Communications (Mar 2018)

TET-mediated epimutagenesis of the Arabidopsis thaliana methylome

Lexiang Ji,
William T. Jordan,
Xiuling Shi,
Lulu Hu,
Chuan He,
Robert J. Schmitz

Affiliations

Lexiang Ji: Institute of Bioinformatics, University of Georgia
William T. Jordan: Department of Genetics, University of Georgia
Xiuling Shi: Department of Genetics, University of Georgia
Lulu Hu: Department of Chemistry, University of Chicago
Chuan He: Department of Chemistry, University of Chicago
Robert J. Schmitz: Department of Genetics, University of Georgia

DOI: https://doi.org/10.1038/s41467-018-03289-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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In plants, variation in DNA methylation can influence agronomically important traits. Here the authors show that expression of a human Ten-eleven translocation enzyme can generate heritable hypomethylation alleles in Arabidopsis, providing a novel method to manipulate DNA methylation for breeding and research purposes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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