Frontiers in Medicine (Dec 2020)

A Retrospective Study of Superficial Type Atypical Lipomatous Tumor

  • Emi Mashima,
  • Yu Sawada,
  • Natsuko Saito-Sasaki,
  • Kayo Yamamoto,
  • Shun Ohmori,
  • Daisuke Omoto,
  • Haruna Yoshioka,
  • Manabu Yoshioka,
  • Etsuko Okada,
  • Takatoshi Aoki,
  • Masanori Hisaoka,
  • Motonobu Nakamura

DOI
https://doi.org/10.3389/fmed.2020.609515
Journal volume & issue
Vol. 7

Abstract

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Atypical lipomatous tumor (ALT) has been defined as a well-differentiated liposarcoma exhibiting a higher frequency of a local recurrence after surgical resection. ALT is mainly classified into deep type and superficial type. Compared with deep type ALT, superficial type ALT is rarely observed. One of the most important issues is that little has been known about superficial type ALT and it is not easy to predict the presence of superficial type ALT before surgical resection. To clarify the clinical manifestations of superficial type ALT, we examined 15 cases with superficial type ALT and 118 cases with benign lipoma, and analyzed their differences in clinical characteristics and the findings of MRI test. In clinical characteristics, the tumor size of superficial type ALT was significantly greater than that of benign lipoma, and superficial type ALT showed a significantly higher frequency of the tumor size of more than 4 cm. Superficial type ALT exhibited poor tumor mobility and hardness with elastic soft. In addition, a significantly higher frequency of tumor location of superficial type ALT was observed in extremities. Among tumor sites at the trunk, buttocks, and shoulder were high frequent location in superficial type ALT. In an MRI examination, superficial type ALT exhibited a significantly higher frequency of the septal structures compared with benign lipoma. The combinations of clinical characteristics, including physical examinations, MRI, and histological examinations, are helpful for the diagnosis of superficial type ALT.

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