A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts

• Bingjie Zhang,
• Simeng Zhao,
• Dehua Yang,
• Yiran Wu,
• Ye Xin,
• Haijie Cao,
• Xi-Ping Huang,
• Xiaoqing Cai,
• Wen Sun,
• Na Ye,
• Yueming Xu,
• Yao Peng,
• Suwen Zhao,
• Zhi-Jie Liu,
• Guisheng Zhong,
• Ming-Wei Wang,
• Wenqing Shui

Affiliations

Bingjie Zhang

iHuman Institute, ShanghaiTech University, Shanghai, China

Simeng Zhao

iHuman Institute, ShanghaiTech University, Shanghai, China

Dehua Yang

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Yiran Wu

iHuman Institute, ShanghaiTech University, Shanghai, China

Ye Xin

iHuman Institute, ShanghaiTech University, Shanghai, China

Haijie Cao

iHuman Institute, ShanghaiTech University, Shanghai, China

Xi-Ping Huang

Department of Pharmacology, NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States

Xiaoqing Cai

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Wen Sun

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Na Ye

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China

Yueming Xu

iHuman Institute, ShanghaiTech University, Shanghai, China

Yao Peng

iHuman Institute, ShanghaiTech University, Shanghai, China

Suwen Zhao

iHuman Institute, ShanghaiTech University, Shanghai, China

Zhi-Jie Liu

iHuman Institute, ShanghaiTech University, Shanghai, China

Guisheng Zhong

iHuman Institute, ShanghaiTech University, Shanghai, China

Ming-Wei Wang

The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Wenqing Shui

iHuman Institute, ShanghaiTech University, Shanghai, China