Running speed and REM sleep control two distinct modes of rapid interhemispheric communication

Megha Ghosh; Fang-Chi Yang; Sharena P. Rice; Vaughn Hetrick; Alcides Lorenzo Gonzalez; Danny Siu; Ellen K.W. Brennan; Tibin T. John; Allison M. Ahrens; Omar J. Ahmed

Cell Reports (Jul 2022)

Running speed and REM sleep control two distinct modes of rapid interhemispheric communication

Megha Ghosh,
Fang-Chi Yang,
Sharena P. Rice,
Vaughn Hetrick,
Alcides Lorenzo Gonzalez,
Danny Siu,
Ellen K.W. Brennan,
Tibin T. John,
Allison M. Ahrens,
Omar J. Ahmed

Affiliations

Megha Ghosh: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Fang-Chi Yang: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Sharena P. Rice: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
Vaughn Hetrick: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Alcides Lorenzo Gonzalez: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
Danny Siu: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Ellen K.W. Brennan: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
Tibin T. John: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
Allison M. Ahrens: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Omar J. Ahmed: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Corresponding author

Journal volume & issue: Vol. 40, no. 1
p. 111028

Abstract

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Summary: Rhythmic gamma-band communication within and across cortical hemispheres is critical for optimal perception, navigation, and memory. Here, using multisite recordings in both rats and mice, we show that even faster ∼140 Hz rhythms are robustly anti-phase across cortical hemispheres, visually resembling splines, the interlocking teeth on mechanical gears. Splines are strongest in superficial granular retrosplenial cortex, a region important for spatial navigation and memory. Spline-frequency interhemispheric communication becomes more coherent and more precisely anti-phase at faster running speeds. Anti-phase splines also demarcate high-activity frames during REM sleep. While splines and associated neuronal spiking are anti-phase across retrosplenial hemispheres during navigation and REM sleep, gamma-rhythmic interhemispheric communication is precisely in-phase. Gamma and splines occur at distinct points of a theta cycle and thus highlight the ability of interhemispheric cortical communication to rapidly switch between in-phase (gamma) and anti-phase (spline) modes within individual theta cycles during both navigation and REM sleep.

CP: Neuroscience

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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