Nature Communications (Jan 2023)

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

  • Lauriane Lecoq,
  • Louis Brigandat,
  • Rebecca Huber,
  • Marie-Laure Fogeron,
  • Shishan Wang,
  • Marie Dujardin,
  • Mathilde Briday,
  • Thomas Wiegand,
  • Morgane Callon,
  • Alexander Malär,
  • David Durantel,
  • Dara Burdette,
  • Jan Martin Berke,
  • Beat H. Meier,
  • Michael Nassal,
  • Anja Böckmann

DOI
https://doi.org/10.1038/s41467-023-36219-3
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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Hepatitis B virus (HBV) capsid assembly modulators (CAM) represent a recent class of anti-HBV antivirals. Structural approaches provide limited conformational information on the CAM-induced off-path assemblies. Here, authors use solid-state NMR to establish a structural view on assembly modulation of the HBV capsid.