Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

Min Hyung Kim; Heekyeong Park; Hyungbeen Lee; Kihwan Nam; Seokhwan Jeong; Inturu Omkaram; Dae Sung Yoon; Sei Young Lee; Sunkook Kim; Sang Woo Lee

doi:10.1063/1.4964488

APL Materials (Oct 2016)

Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

Min Hyung Kim,
Heekyeong Park,
Hyungbeen Lee,
Kihwan Nam,
Seokhwan Jeong,
Inturu Omkaram,
Dae Sung Yoon,
Sei Young Lee,
Sunkook Kim,
Sang Woo Lee

Affiliations

Min Hyung Kim: Department of Biomedical Engineering, Yonsei University, Wonju 26493, South Korea
Heekyeong Park: Multi-Functional Nano/Bio Electronics Laboratory, Kyung Hee University, Gyeonggi 446-701, South Korea
Hyungbeen Lee: Department of Biomedical Engineering, Yonsei University, Wonju 26493, South Korea
Kihwan Nam: Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, South Korea
Seokhwan Jeong: Multi-Functional Nano/Bio Electronics Laboratory, Kyung Hee University, Gyeonggi 446-701, South Korea
Inturu Omkaram: Multi-Functional Nano/Bio Electronics Laboratory, Kyung Hee University, Gyeonggi 446-701, South Korea
Dae Sung Yoon: Department of Bio-convergence Engineering, Korea University, Seoul 136-701, South Korea
Sei Young Lee: Department of Biomedical Engineering, Yonsei University, Wonju 26493, South Korea
Sunkook Kim: Multi-Functional Nano/Bio Electronics Laboratory, Kyung Hee University, Gyeonggi 446-701, South Korea
Sang Woo Lee: Department of Biomedical Engineering, Yonsei University, Wonju 26493, South Korea

DOI: https://doi.org/10.1063/1.4964488
Journal volume & issue: Vol. 4, no. 10
pp. 100701 – 100701-7

Abstract

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We used high-resolution Kelvin probe force microscopy (KPFM) to investigate the immobilization of a prostate specific antigen (PSA) antibody by measuring the surface potential (SP) on a MoS2 surface over an extensive concentration range (1 pg/ml–100 μg/ml). After PSA antibody immobilization, we demonstrated that the SP on the MoS2 surface characterized by KPFM strongly correlated to the electrical signal of a MoS2 bioFET. This demonstration can not only be used to optimize the immobilization conditions for captured molecules, but can also be applied as a diagnostic tool to complement the electrical detection of a MoS2 FET biosensor.

Published in APL Materials

ISSN: 2166-532X (Online)
Publisher: AIP Publishing LLC
Country of publisher: United States
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Physics
Website: http://aplmaterials.aip.org

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