Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles: an approach of overcoming olanzapine drawbacks

Abstract

The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release.

Keywords

• olanzapine
• hepatic metabolism
• solid lipid nanoparticles
• dry adsorbed nanoparticles
• lymphatic uptake
• oral bioavailability