Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis

Abstract

Highlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis. T-CD90@NPs regulate the polarization of type 2 macrophages to resist inflammation. T-CD90@NPs promote chondrocyte regeneration through the FOXO signaling pathway.

Keywords

• Osteoarthritis
• Biomimetic nanoparticles
• CD90+ MCSs-derived micro-vesicle
• Cartilage regeneration
• Anti-inflammatory