Frontiers in Immunology (Jun 2020)
Global Perspectives on Immunization During Pregnancy and Priorities for Future Research and Development: An International Consensus Statement
- Bahaa Abu-Raya,
- Kirsten Maertens,
- Kathryn M. Edwards,
- Saad B. Omer,
- Janet A. Englund,
- Katie L. Flanagan,
- Katie L. Flanagan,
- Katie L. Flanagan,
- Matthew D. Snape,
- Gayatri Amirthalingam,
- Elke Leuridan,
- Pierre Van Damme,
- Vana Papaevangelou,
- Odile Launay,
- Ron Dagan,
- Magda Campins,
- Anna Franca Cavaliere,
- Tiziana Frusca,
- Sofia Guidi,
- Miguel O'Ryan,
- Ulrich Heininger,
- Tina Tan,
- Ahmed R. Alsuwaidi,
- Marco. A. Safadi,
- Luz M. Vilca,
- Nasamon Wanlapakorn,
- Shabir A. Madhi,
- Shabir A. Madhi,
- Michelle L. Giles,
- Roman Prymula,
- Shamez Ladhani,
- Federico Martinón-Torres,
- Litjen Tan,
- Lessandra Michelin,
- Giovanni Scambia,
- Nicola Principi,
- Susanna Esposito
Affiliations
- Bahaa Abu-Raya
- Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
- Kirsten Maertens
- Faculty of Medicine and Health Sciences, Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium
- Kathryn M. Edwards
- Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States
- Saad B. Omer
- Department of Internal Medicine (Infectious Diseases), Department of Epidemiology of Microbial Diseases, Yale School of Medicine, Yale School of Public Health, New Haven, CT, United States
- Janet A. Englund
- Department of Pediatrics, Seattle Children's Research Institute, University of Washington, Seattle, WA, United States
- Katie L. Flanagan
- Faculty of Health Sciences, School of Medicine, University of Tasmania, Launceston, TAS, Australia
- Katie L. Flanagan
- School of Health and Biomedical Science, RMIT University, Melbourne, VIC, Australia
- Katie L. Flanagan
- Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia
- Matthew D. Snape
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
- Gayatri Amirthalingam
- 0Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, United Kingdom
- Elke Leuridan
- Faculty of Medicine and Health Sciences, Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium
- Pierre Van Damme
- Faculty of Medicine and Health Sciences, Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium
- Vana Papaevangelou
- 1Third Department of Pediatrics, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece
- Odile Launay
- 2Université de Paris, Inserm, CIC 1417, F-CRIN I REIVAC, Assistance Publique-Hôpitaux de Paris, Paris, France
- Ron Dagan
- 3The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
- Magda Campins
- 4Preventive Medicine and Epidemiology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain
- Anna Franca Cavaliere
- 5Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario “A. Gemelli” IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy
- Tiziana Frusca
- 6Department of Medicine and Surgery, Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy
- Sofia Guidi
- 5Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario “A. Gemelli” IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy
- Miguel O'Ryan
- 7Microbiology and Mycology Program, Faculty of Medicine, Institute of Biomedical Sciences and Associate Researcher, Millennium Institute of Immunology and Immunotherapy, University of Chile, Santiago, Chile
- Ulrich Heininger
- 8Pediatric Infectious Diseases, University of Basel Children's Hospital, Basel, Switzerland
- Tina Tan
- 9Division of Pediatric Infectious Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States
- Ahmed R. Alsuwaidi
- 0Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
- Marco. A. Safadi
- 1Department of Pediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil
- Luz M. Vilca
- 2Unit of Obstetrics and Gynecology, Buzzi Hospital - ASST Fatebenefratelli Sacco, University of Milan, Milan, Italy
- Nasamon Wanlapakorn
- 3Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
- Shabir A. Madhi
- 4Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- Shabir A. Madhi
- 5Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- Michelle L. Giles
- 6Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia
- Roman Prymula
- 7School of Medicine Hradec Kralove, Institute of Social Medicine, Charles University Prague, Prague, Czechia
- Shamez Ladhani
- 0Immunisation and Countermeasures Division, National Infection Service, Public Health England, London, United Kingdom
- Federico Martinón-Torres
- 8Translational Pediatrics and Infectious Diseases, Pediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, University of Santiago, Santiago de Compostela, Spain
- Litjen Tan
- 9Immunization Action Coalition, St. Paul, MN, United States
- Lessandra Michelin
- 0Infectious Diseases and Vaccinology Division, Health Sciences Post Graduation Program, University of Caxias Do Sul, Caxias Do Sul, Brazil
- Giovanni Scambia
- 5Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario “A. Gemelli” IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy
- Nicola Principi
- 1Università degli Studi di Milano, Milan, Italy
- Susanna Esposito
- 2Department of Medicine and Surgery, Pediatric Clinic, Pietro Barilla Children's Hospital, University of Parma, Parma, Italy
- DOI
- https://doi.org/10.3389/fimmu.2020.01282
- Journal volume & issue
-
Vol. 11
Abstract
Immunization during pregnancy has been recommended in an increasing number of countries. The aim of this strategy is to protect pregnant women and infants from severe infectious disease, morbidity and mortality and is currently limited to tetanus, inactivated influenza, and pertussis-containing vaccines. There have been recent advancements in the development of vaccines designed primarily for use in pregnant women (respiratory syncytial virus and group B Streptococcus vaccines). Although there is increasing evidence to support vaccination in pregnancy, important gaps in knowledge still exist and need to be addressed by future studies. This collaborative consensus paper provides a review of the current literature on immunization during pregnancy and highlights the gaps in knowledge and a consensus of priorities for future research initiatives, in order to optimize protection for both the mother and the infant.
Keywords
- group B Streptococcus vaccines
- influenza
- maternal immunization
- pertussis
- pregnant women
- respiratory syncytial virus
