Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa

Kazuki Fujimoto; Narumi Maki; Daisuke Hashiba; Toshifumi Maeyama; Ryosuke Nakagawa; Hajime Arai; Seiji Ohtori

Osteoporosis and Sarcopenia (Dec 2023)

Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa

Kazuki Fujimoto,
Narumi Maki,
Daisuke Hashiba,
Toshifumi Maeyama,
Ryosuke Nakagawa,
Hajime Arai,
Seiji Ohtori

Affiliations

Kazuki Fujimoto: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan; Corresponding author. Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Narumi Maki: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Daisuke Hashiba: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Toshifumi Maeyama: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Ryosuke Nakagawa: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Hajime Arai: Department of Orthopaedic Surgery, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa City, Chiba, 272-8516, Japan
Seiji Ohtori: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

Journal volume & issue: Vol. 9, no. 4
pp. 137 – 141

Abstract

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Objectives: This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism. Methods: In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab. Results: BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab. Conclusions: Romosozumab is useful for treating osteoporosis in patients with anorexia nervosa.

Published in Osteoporosis and Sarcopenia

ISSN: 2405-5255 (Print)
Publisher: Elsevier
Country of publisher: Korea, Republic of
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: http://www.journals.elsevier.com/osteoporosis-and-sarcopenia/

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