Subiculum as a generator of sharp wave-ripples in the rodent hippocampus
Barbara Imbrosci,
Noam Nitzan,
Sam McKenzie,
José R. Donoso,
Aarti Swaminathan,
Claudia Böhm,
Nikolaus Maier,
Dietmar Schmitz
Affiliations
Barbara Imbrosci
German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Noam Nitzan
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Sam McKenzie
Neuroscience Institute, New York University, New York, NY 10016, USA
José R. Donoso
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany; Bernstein Center for Computational Neuroscience (BCCN) Berlin, 10115 Berlin, Germany
Aarti Swaminathan
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Claudia Böhm
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Nikolaus Maier
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Dietmar Schmitz
German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany; Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany; NeuroCure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany; Bernstein Center for Computational Neuroscience (BCCN) Berlin, 10115 Berlin, Germany; Einstein Center for Neurosciences (ECN) Berlin, 10117 Berlin, Germany; Max-Delbrück-Centrum (MDC) for Molecular Medicine, 13125 Berlin, Germany; Corresponding author
Summary: Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body of evidence suggests that SWRs are exclusively generated in the CA3-CA2 network. In contrast, here, we provide several lines of evidence showing that the subiculum can function as a secondary SWRs generator. SWRs with subicular origin propagate forward into the entorhinal cortex as well as backward into the hippocampus proper. Our findings suggest that the output structures of the hippocampus are not only passively facilitating the transfer of SWRs to the cortex, but they also can actively contribute to the genesis of SWRs. We hypothesize that SWRs with a subicular origin may be important for the consolidation of information conveyed to the hippocampus via the temporoammonic pathway.
