Nature Communications (Mar 2021)
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
- James A. Hutchinson,
- Katharina Kronenberg,
- Paloma Riquelme,
- Jürgen J. Wenzel,
- Gunther Glehr,
- Hannah-Lou Schilling,
- Florian Zeman,
- Katja Evert,
- Martin Schmiedel,
- Marion Mickler,
- Konstantin Drexler,
- Florian Bitterer,
- Laura Cordero,
- Lukas Beyer,
- Christian Bach,
- Josef Koestler,
- Ralph Burkhardt,
- Hans J. Schlitt,
- Dirk Hellwig,
- Jens M. Werner,
- Rainer Spang,
- Barbara Schmidt,
- Edward K. Geissler,
- Sebastian Haferkamp
Affiliations
- James A. Hutchinson
- Department of Surgery, University Hospital Regensburg
- Katharina Kronenberg
- Department of Surgery, University Hospital Regensburg
- Paloma Riquelme
- Department of Surgery, University Hospital Regensburg
- Jürgen J. Wenzel
- Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg
- Gunther Glehr
- Institute of Functional Genomics and Statistical Bioinformatics, University of Regensburg
- Hannah-Lou Schilling
- Department of Surgery, University Hospital Regensburg
- Florian Zeman
- Center for Clinical Studies, University Hospital Regensburg
- Katja Evert
- Institute of Pathology, University Hospital Regensburg
- Martin Schmiedel
- Department of Nuclear Medicine, University Hospital Regensburg
- Marion Mickler
- Department of Dermatology, University Hospital Regensburg
- Konstantin Drexler
- Department of Dermatology, University Hospital Regensburg
- Florian Bitterer
- Department of Surgery, University Hospital Regensburg
- Laura Cordero
- Department of Surgery, University Hospital Regensburg
- Lukas Beyer
- Institute of Radiology, University Hospital Regensburg
- Christian Bach
- Department of Medicine V, University Hospital Erlangen
- Josef Koestler
- Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg
- Ralph Burkhardt
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg
- Hans J. Schlitt
- Department of Surgery, University Hospital Regensburg
- Dirk Hellwig
- Department of Nuclear Medicine, University Hospital Regensburg
- Jens M. Werner
- Department of Surgery, University Hospital Regensburg
- Rainer Spang
- Institute of Functional Genomics and Statistical Bioinformatics, University of Regensburg
- Barbara Schmidt
- Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg
- Edward K. Geissler
- Department of Surgery, University Hospital Regensburg
- Sebastian Haferkamp
- Department of Dermatology, University Hospital Regensburg
- DOI
- https://doi.org/10.1038/s41467-021-21572-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients.
