Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Abstract

Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor of the ferroptosis pathway. This study investigates the influence of DHODH on the progression of malignant tumors, including its important role in the de novo synthesis of pyrimidine, oxidative phosphorylation, and ferroptosis. The objective is to present evidence that DHODH is a potential target for the clinical treatment of tumors.

Keywords

• dihydroorotate dehydrogenase
• neoplasms
• de novo pyrimidine biosynthesis
• oxphos
• ferroptosis
• dhodh inhibitor