Masson pine pollen aqueous extract ameliorates cadmium-induced kidney damage in rats

Zhiyong Hu; Sixin Chen; Tala Shi; Zhaoju Dong; Mei Cheng; Ning Li; Huijuan Zhao; Haibo Zhu; Chunlei Han; Lanlan Xu

doi:10.3389/fmolb.2023.1249744

Frontiers in Molecular Biosciences (Dec 2023)

Masson pine pollen aqueous extract ameliorates cadmium-induced kidney damage in rats

Zhiyong Hu,
Sixin Chen,
Tala Shi,
Zhaoju Dong,
Mei Cheng,
Ning Li,
Huijuan Zhao,
Haibo Zhu,
Chunlei Han,
Lanlan Xu

Affiliations

Zhiyong Hu: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Sixin Chen: School of Public Health and Management, Binzhou Medical University, Yantai, China
Tala Shi: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Zhaoju Dong: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Mei Cheng: Department of Health and Disease Management, Binzhou Medical University, Yantai, China
Ning Li: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Huijuan Zhao: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Haibo Zhu: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Chunlei Han: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China
Lanlan Xu: Department of Occupational Health and Environmental Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai, China

DOI: https://doi.org/10.3389/fmolb.2023.1249744
Journal volume & issue: Vol. 10

Abstract

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Introduction: Cadmium (Cd) is a hazardous environmental pollutant present in soil, water, and food. Accumulation of Cd in organisms can cause systematic injury and damage to the kidney. The Masson pine pollen aqueous extract (MPPAE) has attracted increasing attention due to its antioxidant activity and ability to enhance immunity.Methods: In this study, we investigated the potential of MPPAE to protect against Cd-induced kidney damage in rats and the underlying mechanism. The transcriptome and metabolome of rats with Cd-induced kidney damage, following treatment with MPPAE, were explored.Results: The concentrations of superoxide dismutase (SOD) and malondialdehyde (MDA) were both significantly altered after treatment with MPPAE. Furthermore, sequencing and analysis of the transcriptome and metabolome of rats with Cd-induced kidney damage, following treatment with MPPAE, revealed differential expression of numerous genes and metabolites compared with the untreated control rats. These differentially expressed genes (DEGs) included detoxification-related genes such as cytochrome P450 and the transporter. The differentially expressed metabolites (DEMs) included 4-hydroxybenzoic acid, L-ascorbate, and ciliatine. Conjoint transcriptome and metabolome analysis showed that several DEGs were correlated with DEMs.Conclusion: These preliminary findings indicate the potential of MPPAE for the treatment of toxic metal poisoning.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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