Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Feixiang Yang; Feixiang Yang; Feixiang Yang; Feixiang Yang; Ning Zhang; Ning Zhang; Yuxin Chen; Yuxin Chen; Jiancai Yin; Muchen Xu; Muchen Xu; Xiang Cheng; Ruyi Ma; Jialin Meng; Jialin Meng; Jialin Meng; Yinan Du

doi:10.3389/fcimb.2022.873304

Frontiers in Cellular and Infection Microbiology (Apr 2022)

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Feixiang Yang,
Feixiang Yang,
Feixiang Yang,
Feixiang Yang,
Ning Zhang,
Ning Zhang,
Yuxin Chen,
Yuxin Chen,
Jiancai Yin,
Muchen Xu,
Muchen Xu,
Xiang Cheng,
Ruyi Ma,
Jialin Meng,
Jialin Meng,
Jialin Meng,
Yinan Du

Affiliations

Feixiang Yang: School of Basic Medical Sciences, Anhui Medical University, Hefei, China
Feixiang Yang: Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Feixiang Yang: Institute of Urology, Anhui Medical University, Hefei, China
Feixiang Yang: Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China
Ning Zhang: School of Basic Medical Sciences, Anhui Medical University, Hefei, China
Ning Zhang: First School of Clinical Medicine, Anhui Medical University, Hefei, China
Yuxin Chen: School of Basic Medical Sciences, Anhui Medical University, Hefei, China
Yuxin Chen: School of Public Health, Anhui Medical University, Hefei, China
Jiancai Yin: First School of Clinical Medicine, Anhui Medical University, Hefei, China
Muchen Xu: School of Basic Medical Sciences, Anhui Medical University, Hefei, China
Muchen Xu: School of Public Health, Anhui Medical University, Hefei, China
Xiang Cheng: First School of Clinical Medicine, Anhui Medical University, Hefei, China
Ruyi Ma: School of Basic Medical Sciences, Anhui Medical University, Hefei, China
Jialin Meng: Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Jialin Meng: Institute of Urology, Anhui Medical University, Hefei, China
Jialin Meng: Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China
Yinan Du: School of Basic Medical Sciences, Anhui Medical University, Hefei, China

DOI: https://doi.org/10.3389/fcimb.2022.873304
Journal volume & issue: Vol. 12

Abstract

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Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Non-coding RNAs (ncRNAs), are RNAs that do not code for proteins, play a key role in biological processes and disease development associated with EV71. In this review, we summarized recent advances concerning the impacts of ncRNAs on neurological diseases caused by interaction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, diagnosis and treatment of EV71-induced neurological complications.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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